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Further data are available from the corresponding author upon request

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In addition to the regulation of this main transcription loop, CLOCK/BMAL1 stimulates the expression of other clock-related transcriptions, such as REV-ERB , retinoic acid-borne orphaned binders a ( ROR ), DEC1 , DEC2 , and albumin D-binding ( DBP ), which form an auxiliary loop that stabilizes the main regulatory loop (Ripperger and Schibler, 2006

The fermentation-based manufacturing process ensures high purity and consistent quality, which supports reliable results